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SMG6 Monoklonaler Antikörper

SMG6 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1D2G2

Kat-Nr. : 68109-1-PBS

Synonyme

C17orf31, EST1 like protein A, EST1A, Ever shorter telomeres 1A, hSmg5/7a, KIAA0732, SMG 6, Smg 6 homolog, SMG6, Telomerase subunit EST1A

Filter:
  • Western Blot (WB) analysis of various lysates using SMG6 Monoclonal antibody (68109-1-Ig)

    WB analysis using 68109-1-Ig (same clone as 68109-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68109-1-Ig (SMG6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with Lamin B1 Monoclonal antibody (66095-1-Ig) as loading control. This data was developed using the same antibody clone with 68109-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of RAW 264.7 cells using SMG6 Monoclonal antibody (68109-1-Ig)

    WB analysis of RAW 264.7 using 68109-1-Ig (same clone as 68109-1-PBS)

    RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 68109-1-Ig (SMG6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68109-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68109-1-PBS bindet in WB, Indirect ELISA SMG6 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen SMG6 fusion protein Ag30182
Vollständiger Name Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Berechnetes Molekulargewicht 160 kDa
Beobachtetes Molekulargewicht160 kDa
GenBank-ZugangsnummerNM_017575
Gene symbol SMG6
Gene ID (NCBI) 23293
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SMG6, also known as C17orf31, EST1A, and hEST1A, is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PMID: 19179534). It promotes in vitro the ability of TERT to elongate telomeres (PMID: 12676087, 12699629). SMG6 also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD (PMID: 19060897, 20930030). Alternate splicing results in multiple transcript variants (PMID: 12699629, 14636577).