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SP7 Rekombinanter Antikörper

SP7 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250286C5

Kat-Nr. : 85934-1-PBS

Synonyme

osterix, OSX, Sp7 transcription factor, Transcription factor Sp7, Zinc finger protein osterix

Filter:
  • Western Blot (WB) analysis of various lysates using SP7 Recombinant antibody (85934-1-RR)

    WB analysis using 85934-1-RR (same clone as 85934-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85934-1-RR (SP7 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85934-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85934-1-RR

    Affinity and Kinetic Characterization of 85934-1-RR

    Biolayer interferometry (BLl) kinetic assays of 85934-1-RR against Human SP7 were performed. The affinity constant is 1.10 nM.

Geprüfte Anwendungen

Produktinformation

85934-1-PBS bindet in WB, Indirect ELISA SP7 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen SP7 fusion protein Ag29889
Vollständiger Name Sp7 transcription factor
Berechnetes Molekulargewicht 45 kDa
Beobachtetes Molekulargewicht 45 kDa
GenBank-ZugangsnummerNM_152860
Gene symbol SP7
Gene ID (NCBI) 121340
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Sp7 is identified in several tissues, including bone, tooth, brain, and the reproductive tract (PMID: 11792318, 33135214, 36881265). In bone, Sp7 is expressed at multiple stages throughout the mesenchymal bone lineage and plays different roles in different osteocytes (PMID: 36881265). SP7 regulates osteoblast differentiation and bone formation through osteoblast target genes by recognizing AT-rich region. In osteocytes, SP7 regulates osteocyte maturation and intracortical remodeling through osteocyte target genes by recognizing TGA(G/T) TCA motif. SP7 also regulates chondrocyte differentiation and endochondral ossification (36881265).