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SPHK2 Monoklonaler Antikörper

SPHK2 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2B5G5

Kat-Nr. : 68871-4-PBS

Synonyme

2B5G5, EC:2.7.1.91, SK 2, SK-2, Sphingosine kinase 2

Filter:
  • Western Blot (WB) analysis of various lysates using SPHK2 Monoclonal antibody (68871-4-Ig)

    WB analysis using 68871-4-Ig (same clone as 68871-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68871-4-Ig (SPHK2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68871-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68871-4-PBS bindet in WB, Indirect ELISA SPHK2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen SPHK2 fusion protein Ag10569
Vollständiger Name sphingosine kinase 2
Berechnetes Molekulargewicht 618 aa, 65 kDa
Beobachtetes Molekulargewicht 65-70 kDa
GenBank-ZugangsnummerBC010671
Gene symbol SPHK2
Gene ID (NCBI) 56848
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SPHK2(Sphingosine kinase 2) is also named as SK2, SPK2 and catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. SPHK2 associates with HDAC1 and HDAC2 in repressor complexes and is selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription.SphK2 is a ~66kDa protein that is most abundantly expressed in the liver and heart(PMID:19168577). SphK2 has two splice variants, which are the 68-kDa SphK2-S and the NH2-terminal extended 72-kDa SphK2-L (PMID:17974990).