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SRPK2 Rekombinanter Antikörper

SRPK2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242935B1

Kat-Nr. : 85613-5-PBS

Synonyme

EC:2.7.11.1, Serine/arginine-rich protein-specific kinase 2, SFRS protein kinase 2, SFRSK2, SR protein specific kinase 2

Filter:
  • Western Blot (WB) analysis of various lysates using SRPK2 Recombinant antibody (85613-5-RR)

    WB analysis using 85613-5-RR (same clone as 85613-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85613-5-RR (SRPK2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85613-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85613-5-RR

    Affinity and Kinetic Characterization of 85613-5-RR

    Biolayer interferometry (BLl) kinetic assays of 85613-5-RR against Human SRPK2 were performed. The affinity constant is 4.16 nM.

Geprüfte Anwendungen

Produktinformation

85613-5-PBS bindet in WB, Indirect ELISA SRPK2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen SRPK2 fusion protein Ag17885
Vollständiger Name SFRS protein kinase 2
Berechnetes Molekulargewicht 688 aa, 78 kDa
Beobachtetes Molekulargewicht 105-110 kDa
GenBank-ZugangsnummerBC035214
Gene symbol SRPK2
Gene ID (NCBI) 6733
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SRPK2, also named as serine/arginine protein kinase 2 and SFRSK2, belongs to SR protein-specific kinase family which phosphorylate the serine/arginine domain containing proteins in the nuclear speckles to mediate pre-mRNA splicing (PMID: 22854045). In addition to its major role as kinase for the phosphorylation of SR proteins, SRPK2 is involved in cell cycle regulation and cell apoptosis (PMID: 19592491). SRPK2 promotes the proliferation and migration of the colon cancer cells. It has been reported to be regulated in several cancer types (PMID: 27041240). It has 2 isoforms with the calculated molecular mass of 77-79 kDa, and the apparent molecular mass of 105-115 kDa due to posttranslational modification (PMID: 12134018, 16122776).