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STIM2 Rekombinanter Antikörper

STIM2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250016E8

Kat-Nr. : 85727-1-PBS

Synonyme

KIAA1482, Stromal interaction molecule 2

Filter:
  • Western Blot (WB) analysis of various lysates using STIM2 Recombinant antibody (85727-1-RR)

    WB analysis using 85727-1-RR (same clone as 85727-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85727-1-RR (STIM2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85727-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85727-1-RR

    Affinity and Kinetic Characterization of 85727-1-RR

    Biolayer interferometry (BLl) kinetic assays of 85727-1-RR against Human STIM2 were performed. The affinity constant is 0.774 nM.

Geprüfte Anwendungen

Produktinformation

85727-1-PBS bindet in WB, Indirect ELISA STIM2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen STIM2 fusion protein Ag15530
Vollständiger Name stromal interaction molecule 2
Berechnetes Molekulargewicht 754 aa, 85 kDa
Beobachtetes Molekulargewicht 85-115 kDa
GenBank-ZugangsnummerBC146661
Gene symbol STIM2
Gene ID (NCBI) 57620
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

STIM2, also named as KIAA1482, functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, STIM2 translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. STIM2 may inhibit STIM1-mediated Ca2+ influx. STIM2 has 2 isoforms 105kd and 115kd with Differential levels of phosphorylation.