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STT3A Rekombinanter Antikörper

STT3A Rekombinant Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

ELISA

Konjugation

Unkonjugiert

CloneNo.

230426B10

Kat-Nr. : 83077-4-RR

Synonyme

ITM1, Integral membrane protein 1, EC:2.4.99.18, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, B5

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  • Affinity and Kinetic Characterization of 83077-4-RR

    Affinity and Kinetic Characterization of 83077-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83077-4-RR against Human STT3A were performed. The affinity constant is 9.73 nM.

Geprüfte Anwendungen

Produktinformation

83077-4-RR bindet in ELISA STT3A und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen STT3A fusion protein Ag31994
Vollständiger Name STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Berechnetes Molekulargewicht 705 aa, 81 kDa
GenBank-ZugangsnummerBC020965
Gene symbol STT3A
Gene ID (NCBI) 3703
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

STT3A, also named as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, is a 705 amino acid prtein, which belongs to the STT3 family. STT3A is expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in brain, lung and kidney. STT3A is a catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.