SUR1 Polyklonaler Antikörper

SUR1 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 55172-1-AP

Synonyme

ABC36, ABCC8, HHF1, HI, HRINS, MRP8, PHHI, Sulfonylurea receptor 1, SUR, SUR1, TNDM2

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Galerie der Validierungsdaten

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  WB analysis using 55172-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 55172-1-AP (SUR1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 55172-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 55172-1-AP (SUR1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: A549-Zellen, BxPC-3-Zellen, Maushirngewebe, NCI-H1299-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

55172-1-AP bindet in WB, ELISA SUR1 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
• Berechnetes Molekulargewicht: 177 kDa
• Beobachtetes Molekulargewicht: 140–177 kDa
• GenBank-Zugangsnummer: NM_000352
• Gene symbol: ABCC8
• Gene ID (NCBI): 6833
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SUR1 (Sulfonylurea receptor 1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, which encompasses a large group of membrane proteins that regulate the transport of ions and molecules across lipid bilayers (PMID:34769328). SUR1 regulates ATP-sensitive K+ channels and insulin release. Loss-of-function SUR1 mutations cause congenital hyperinsulinism and gain-of-function SUR1 mutations leading to neonatal diabetes (PMID: 18990670). SUR1 is recognized as a key mediator of central nervous system cellular swelling by the transient receptor potential melastatin 4 (TRPM4) channel. SUR1 (Sulfonylurea receptor 1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, which encompasses a large group of membrane proteins that regulate the transport of ions and molecules across lipid bilayers (PMID:34769328). SUR1 regulates ATP-sensitive K+ channels and insulin release. Loss-of-function SUR1 mutations cause congenital hyperinsulinism and gain-of-function SUR1 mutations leading to neonatal diabetes (PMID: 18990670). SUR1 is recognized as a key mediator of central nervous system cellular swelling by the transient receptor potential melastatin 4 (TRPM4) channel. SUR1 was detected 140-177 kDa in the pancreas, brain, heart (PMID: 34380876).