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SUR1 Polyklonaler Antikörper

SUR1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 55172-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using SUR1 Polyclonal antibody (55172-1-AP)

    WB analysis using 55172-1-AP (same clone as 55172-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 55172-1-AP (SUR1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55172-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using SUR1 Polyclonal antibody (55172-1-AP)

    WB analysis using 55172-1-AP (same clone as 55172-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 55172-1-AP (SUR1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55172-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

55172-1-PBS bindet in WB, Indirect ELISA SUR1 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Berechnetes Molekulargewicht 177 kDa
Beobachtetes Molekulargewicht140–177 kDa
GenBank-ZugangsnummerNM_000352
Gene symbol SUR1
Gene ID (NCBI) 6833
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SUR1 (Sulfonylurea receptor 1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, which encompasses a large group of membrane proteins that regulate the transport of ions and molecules across lipid bilayers (PMID:34769328). SUR1 regulates ATP-sensitive K+ channels and insulin release. Loss-of-function SUR1 mutations cause congenital hyperinsulinism and gain-of-function SUR1 mutations leading to neonatal diabetes (PMID: 18990670). SUR1 is recognized as a key mediator of central nervous system cellular swelling by the transient receptor potential melastatin 4 (TRPM4) channel. SUR1 (Sulfonylurea receptor 1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, which encompasses a large group of membrane proteins that regulate the transport of ions and molecules across lipid bilayers (PMID:34769328). SUR1 regulates ATP-sensitive K+ channels and insulin release. Loss-of-function SUR1 mutations cause congenital hyperinsulinism and gain-of-function SUR1 mutations leading to neonatal diabetes (PMID: 18990670). SUR1 is recognized as a key mediator of central nervous system cellular swelling by the transient receptor potential melastatin 4 (TRPM4) channel. SUR1 was detected 140-177 kDa in the pancreas, brain, heart (PMID: 34380876).