SUZ12 Polyklonaler Antikörper

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SUZ12 Polyklonal Antikörper für WB, IHC, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Ratte

Anwendung

WB, IHC, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20366-1-PBS

Synonyme

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  WB analysis using 20366-1-AP (same clone as 20366-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 20366-1-AP (SUZ12 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HEK-293 using 20366-1-AP (same clone as 20366-1-PBS)

  WB result of SUZ12 antibody (20366-1-AP; 1:1200; incubated at room temperature for 1.5 hours) with sh-Control and sh-SUZ12 transfected HEK-293 cells. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IP experiment of HeLa using 20366-1-AP (same clone as 20366-1-PBS)

  IP result of anti-SUZ12 (IP:20366-1-AP, 4ug; Detection:20366-1-AP 1:500) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IP experiment of HeLa using 20366-1-AP (same clone as 20366-1-PBS)

  IP result of anti-SUZ12 (IP:20366-1-AP, 4ug; Detection:20366-1-AP 1:500) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:400. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:100. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:100. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:200. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:200. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:400. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

20366-1-PBS bindet in WB, IHC, IP, Indirect ELISA SUZ12 und zeigt Reaktivität mit human, Ratten

• Getestete Reaktivität: human, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: suppressor of zeste 12 homolog (Drosophila)
• Berechnetes Molekulargewicht: 83 kDa
• Beobachtetes Molekulargewicht: 80-90 kDa
• GenBank-Zugangsnummer: NM_015355
• Gene symbol: SUZ12
• Gene ID (NCBI): 23512
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SUZ12, also termed CHET9, JJAZ1 or KIAA0160, belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. It is a polycomb group (PcG) protein. SUZ12 is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors.