SVIP Polyklonaler Antikörper

SVIP Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32511-1-PBS

Synonyme

Small VCP/p97-interacting protein

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  WB analysis using 32511-1-AP (same clone as 32511-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32511-1-AP (SVIP antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32511-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

32511-1-PBS bindet in WB, Indirect ELISA SVIP und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: SVIP fusion protein Ag36618
• Vollständiger Name: small VCP/p97-interacting protein
• Berechnetes Molekulargewicht: 8kDa
• Beobachtetes Molekulargewicht: 12 kDa
• GenBank-Zugangsnummer: NM_001320340
• Gene symbol: SVIP
• Gene ID (NCBI): 258010
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SVIP (Small VCP-interacting protein) is a 9-Kda adaptor endoplasmic reticulum protein that could bind directly to p97/VCP. SVIP is located on the ER membrane's cytosolic surface. It inhibits the ERAD pathway, which is known independently of ubiquitin, by interacting with p97/VCP, which has a central role in this pathway. Especially for the ERAD pathway, the SVIP protein has been identified as a negative regulator. SVIP was identified as a novel adapter protein for p97/VCP by observing its overexpression in cells, which causes extensive vacuolation and deformation of the ER and microtubules (PMID: 39473740).