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SYNGAP1 Rekombinanter Antikörper

SYNGAP1 Rekombinant Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242255E3

Kat-Nr. : 85045-1-PBS

Synonyme

Synaptic Ras GTPase-activating protein 1, RASA 1, Ras/Rap GTPase-activating protein SynGAP, Ras GTPase activating protein SynGAP, Neuronal RasGAP

Filter:
  • Western Blot (WB) analysis of various lysates using SYNGAP1 Recombinant antibody (85045-1-RR)

    WB analysis using 85045-1-RR (same clone as 85045-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85045-1-RR (SYNGAP1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85045-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of U-251 cells using SYNGAP1 Recombinant antibody (85045-1-RR)

    IF Staining of U-251 using 85045-1-RR (same clone as 85045-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U-251 cells using SYNGAP1 antibody (85045-1-RR, Clone: 242255E3 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 85045-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85045-1-PBS bindet in WB, IF/ICC, Indirect ELISA SYNGAP1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name synaptic Ras GTPase activating protein 1 homolog (rat)
Berechnetes Molekulargewicht 1343 aa, 148 kDa
Beobachtetes Molekulargewicht140 kDa
GenBank-ZugangsnummerNM_006772
Gene symbol SYNGAP1
Gene ID (NCBI) 8831
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SYNGAP1, also named as KIAA1938, is the major constituent of the PSD essential for postsynaptic signaling. It's an inhibitory regulator of the Ras-cAMP pathway. SYNGAP1 is a member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. SYNGAP1 regulates AMPAR-mediated miniature excitatory postsynaptic currents. SYNGAP1 may be involved in certain forms of brain injury, leading to long-term learning and memory deficits Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5).