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Serpin A4/Kallistatin Rekombinanter Antikörper

Serpin A4/Kallistatin Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251716C12

Kat-Nr. : 86758-3-PBS

Synonyme

Kallistatin, Serpin A4, KAL, Kallikrein inhibitor, KLST

Filter:
  • Western Blot (WB) analysis of human plasma using Serpin A4/Kallistatin Recombinant monoclonal antib (86758-3-RR)

    WB analysis of human plasma using 86758-3-RR (same clone as 86758-3-PBS)

    Human plasma was subjected to SDS PAGE followed by western blot with 86758-3-RR (Serpin A4/Kallistatin antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86758-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86758-3-PBS bindet in WB, Indirect ELISA Serpin A4/Kallistatin und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Serpin A4/Kallistatin fusion protein Eg4707
Vollständiger Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Berechnetes Molekulargewicht49 kDa
Beobachtetes Molekulargewicht 49 kDa
GenBank-ZugangsnummerNM_001289033.1
Gene symbol Kallistatin
Gene ID (NCBI) 5267
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Serpin A4 is also named Kallistatin and Peptidase inhibitor 4 (PI-4). Kallistatin was first identified in human plasma as a tissue kallikrein-binding protein and a serine proteinase inhibitor. Kallistatin via its two structural elements regulates differential signaling cascades, and thus a wide spectrum of biological functions (PMID: 28427524). Kallistatin via the active site promotes neovascularization by stimulating VEGF levels in endothelial progenitor cells. Second, kallistatin inhibits or induces apoptosis depending on cell types. Kallistatin via its heparin-binding site inhibits angiogenesis by blocking vascular endothelial growth factor (VEGF)-induced growth, migration and adhesion of endothelial cells. Kallistatin can act as an antioxidant or pro-oxidant (PMID: 28742513).