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Serpin B3/4 Rekombinanter Antikörper

Serpin B3/4 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250057B3

Kat-Nr. : 85807-2-PBS

Synonyme

SERPINB3, SERPINB3/4, Protein T4 A, Protein T4-A, SCCA-1

Filter:
  • Western Blot (WB) analysis of various lysates using Serpin B3/4 Recombinant antibody (85807-2-RR)

    WB analysis using 85807-2-RR (same clone as 85807-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85807-2-RR (SERPINB3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85807-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85807-2-RR

    Affinity and Kinetic Characterization of 85807-2-RR

    Biolayer interferometry (BLl) kinetic assays of 85807-2-RR against Human Serpin B3/4 were performed. The affinity constant is 0.95 nM.

Geprüfte Anwendungen

Produktinformation

85807-2-PBS bindet in WB, Indirect ELISA Serpin B3/4 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Serpin B3/4 fusion protein Ag24846
Vollständiger Name serpin peptidase inhibitor, clade B (ovalbumin), member 3
Berechnetes Molekulargewicht 390 aa, 45 kDa
Beobachtetes Molekulargewicht45 kDa
GenBank-ZugangsnummerBC005224
Gene symbol SERPINB3
Gene ID (NCBI) 6317
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4) are members of the ovalbumin family of serine proteinase inhibitors. SCCA1 and SCCA2 are highly homologous proteins, 91% identical at the amino acid level, and probably evolving from a common ancestor gene. The neutral form of SCCA (SCCA1, or SERPINB3) is detected in the cytoplasm of normal and some malignant squamous cells, whereas the acidic form (SCCA2, or SERPINB4) is expressed primarily in malignant cells and is the major form found in the plasma of cancer patients. SCCA2 (SERPINB4), along with SCCA1(SERPINB3), can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. This antibody can recognize both SerpinB3 and SerpinB4.