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SerpinB3/SerpinB4 Polyklonaler Antikörper

SerpinB3/SerpinB4 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11428-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using SerpinB3/SerpinB4 Polyclonal antibody (11428-1-AP)

    WB analysis using 11428-1-AP (same clone as 11428-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11428-1-AP (SERPINB4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11428-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of COLO 320 cells using SerpinB3/SerpinB4 Polyclonal antibody (11428-1-AP)

    WB analysis of COLO 320 using 11428-1-AP (same clone as 11428-1-PBS)

    COLO 320 cells were subjected to SDS PAGE followed by western blot with 11428-1-AP (SERPINB4 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11428-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

11428-1-PBS bindet in WB, Indirect ELISA SerpinB3/SerpinB4 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SerpinB3/SerpinB4 fusion protein Ag1964
Vollständiger Name serpin peptidase inhibitor, clade B (ovalbumin), member 4
Berechnetes Molekulargewicht 390 aa, 45 kDa
Beobachtetes Molekulargewicht42-45 kDa
GenBank-ZugangsnummerBC017401
Gene symbol SERPINB4
Gene ID (NCBI) 6318
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4) are members of the ovalbumin family of serine proteinase inhibitors. SCCA1 and SCCA2 are highly homologous proteins, 91% identical at the amino acid level, and probably evolving from a common ancestor gene. The neutral form of SCCA (SCCA1, or SERPINB3) is detected in the cytoplasm of normal and some malignant squamous cells, whereas the acidic form (SCCA2, or SERPINB4) is expressed primarily in malignant cells and is the major form found in the plasma of cancer patients. SCCA2 (SERPINB4), along with SCCA1(SERPINB3), can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. This antibody can recognize both SerpinB3 and SerpinB4.