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Siglec-7/CD328 Rekombinanter Antikörper

Siglec-7/CD328 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241525H1

Kat-Nr. : 98183-1-PBS

Synonyme

SIGLEC7, Siglec-7, D siglec, CD328, AIRM-1

Filter:
  • Flow cytometry (FC) experiment of human peripheral blood leukocytes using Anti-Human Siglec-7/CD328 Rabbit Recombinant Antib (98183-1-RR)

    FC experiment of human peripheral blood leukocytes using 98183-1-RR (same clone as 98183-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human Siglec-7/CD328 Rabbit Recombinant Antibody (98183-1-RR, Clone: 241525H1) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were not fixed. This data was developed using the same antibody clone with 98183-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human peripheral blood leukocytes using Anti-Human Siglec-7/CD328 Rabbit Recombinant Antib (98183-1-RR)

    FC experiment of human peripheral blood leukocytes using 98183-1-RR (same clone as 98183-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human Siglec-7/CD328 Rabbit Recombinant Antibody (98183-1-RR, Clone:241525H1) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98183-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98183-1-RR

    Affinity and Kinetic Characterization of 98183-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98183-1-RR against Human Siglec-7/CD328 were performed. The affinity constant is 0.22 nM.

Geprüfte Anwendungen

Produktinformation

98183-1-PBS bindet in FC Siglec-7/CD328 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name sialic acid binding Ig-like lectin 7
Berechnetes Molekulargewicht51 kDa
GenBank-ZugangsnummerNM_014385.4
Gene symbol Siglec-7
Gene ID (NCBI) 27036
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

Sialic acid binding Ig-like lectin 7 (Siglec-7), also known as CD328 or p75/AIRM-1, is a member of the Siglec family of glycan-recognition proteins. Siglec-7 is a type-I transmembrane protein consisting of three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibition motif-like motifs (PMID: 32322597; 10567377). It is mainly expressed on immune cells, with low levels on granulocytes, intermediate levels on monocytes, and relatively high levels on a major subset of natural killer cells and a minor subset of CD8+ T cells (PMID: 10567377). Siglec-7 is an inhibitory receptor that negatively regulates the function of NK cells and modulates the immune response through the interaction of sialic acid-containing ligands (PMID: 27312286).