Siglec-7/CD328 Rekombinanter Antikörper
Siglec-7/CD328 Rekombinant Antikörper für
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
Konjugation
CoraLite®488 Fluorescent Dye
CloneNo.
241525H1
Kat-Nr. : CL488-98183
Synonyme
Geprüfte Anwendungen
Produktinformation
CL488-98183 bindet in Siglec-7/CD328 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Rekombinant |
| Typ | Antikörper |
| Immunogen | Siglec-7/CD328 fusion protein Eg1545 |
| Vollständiger Name | sialic acid binding Ig-like lectin 7 |
| Berechnetes Molekulargewicht | 51 kDa |
| GenBank-Zugangsnummer | NM_014385.4 |
| Gene symbol | Siglec-7 |
| Gene ID (NCBI) | 27036 |
| Konjugation | CoraLite®488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 491 nm / 516 nm |
| Form | Liquid |
| Reinigungsmethode | Protein A purfication |
| Lagerungspuffer | PBS with 0.09% sodium azide and 0.5% BSA |
| Lagerungsbedingungen | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Hintergrundinformationen
Sialic acid binding Ig-like lectin 7 (Siglec-7), also known as CD328 or p75/AIRM-1, is a member of the Siglec family of glycan-recognition proteins. Siglec-7 is a type-I transmembrane protein consisting of three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibition motif-like motifs (PMID: 32322597; 10567377). It is mainly expressed on immune cells, with low levels on granulocytes, intermediate levels on monocytes, and relatively high levels on a major subset of natural killer cells and a minor subset of CD8+ T cells (PMID: 10567377). Siglec-7 is an inhibitory receptor that negatively regulates the function of NK cells and modulates the immune response through the interaction of sialic acid-containing ligands (PMID: 27312286).
