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Siglec-9 Rekombinanter Antikörper

Siglec-9 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241799E8

Kat-Nr. : 84683-4-PBS

Synonyme

SIGLEC9, Siglec 9, Sialic acid-binding Ig-like lectin 9, Protein FOAP 9, CD329

Filter:
  • Western Blot (WB) analysis of various lysates using Siglec-9 Recombinant antibody (84683-4-RR)

    WB analysis using 84683-4-RR (same clone as 84683-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84683-4-RR (Siglec-9 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84683-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84683-4-RR

    Affinity and Kinetic Characterization of 84683-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84683-4-RR against Human Siglec-9 were performed. The affinity constant is 0.492 nM.

Geprüfte Anwendungen

Produktinformation

84683-4-PBS bindet in WB, Indirect ELISA Siglec-9 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name sialic acid binding Ig-like lectin 9
Berechnetes Molekulargewicht50 kDa
Beobachtetes Molekulargewicht50 kDa
GenBank-ZugangsnummerNM_014441.3
Gene symbol Siglec-9
Gene ID (NCBI) 27180
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Sialic acid binding Ig-like lectin 9 (Siglec-9), also known as CD329, is a member of the Siglec family of glycan-recognition proteins. Siglec-9 is a type-I transmembrane protein consisting of an N-terminal extracellular region that contains an N-terminal V-set domain and two C2-set domains, a transmembrane region, and an intracellular domain with an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an ITIM-like motif (PMID: 10801862). It is expressed quite broadly among human blood leukocytes, including monocytes, neutrophils, B cells, NK cells, and minor subsets of T cells (PMID: 32322597). Siglec-9 functions as an inhibitory immune checkpoint and can be targeted to enhance therapeutic antitumor immunity (PMID: 34155121; 37460871).