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Spartin/SPG20 Rekombinanter Antikörper

Spartin/SPG20 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250440A11

Kat-Nr. : 85938-2-PBS

Synonyme

SPG20, KIAA0610, SPART, Spartin, SPG 20

Filter:
  • Western Blot (WB) analysis of various lysates using Spartin/SPG20 Recombinant antibody (85938-2-RR)

    WB analysis using 85938-2-RR (same clone as 85938-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85938-2-RR (Spartin/SPG20 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85938-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85938-2-RR

    Affinity and Kinetic Characterization of 85938-2-RR

    Biolayer interferometry (BLl) kinetic assays of 85938-2-RR against Human Spartin/SPG20 were performed. The affinity constant is 1.66 nM.

Geprüfte Anwendungen

Produktinformation

85938-2-PBS bindet in WB, Indirect ELISA Spartin/SPG20 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Spartin/SPG20 fusion protein Ag4815
Vollständiger Name spastic paraplegia 20 (Troyer syndrome)
Berechnetes Molekulargewicht 72 kDa
Beobachtetes Molekulargewicht 75-84 kDa
GenBank-ZugangsnummerBC047083
Gene symbol Spartin
Gene ID (NCBI) 23111
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SPG20 (spastic paraplegia 20) gene encodes a multifunctional Spartin protein. SPG20 protein is highly expressed in adipose tissue and may be implicated in endosomal trafficking and microtubule dynamics. SPG20 is mutated in Troyer syndrome, a hereditary spastic paraplegia defined by degeneration of upper motor neurons, recent study showed that regulation of SPG20 on mitochondrial calcium homeostasis may contribute to the pathophysiology of Troyer syndrome. Hypermethylation of SPG20 promoter, found in colorectal cancer patients, may play a role in cytokinesis arrest in colorectal tumorigenesis.