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TACC2 Polyklonaler Antikörper

TACC2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11407-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of mouse testis tissue using TACC2 Polyclonal antibody (11407-1-AP)

    WB analysis of mouse testis using 11407-1-AP (same clone as 11407-1-PBS)

    mouse testis tissue were subjected to SDS PAGE followed by western blot with 11407-1-AP (TACC2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11407-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung cancer tissue using TACC2 Polyclonal antibody (11407-1-AP)

    IHC staining of human lung cancer using 11407-1-AP (same clone as 11407-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11407-1-AP (TACC2 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11407-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung cancer tissue using TACC2 Polyclonal antibody (11407-1-AP)

    IHC staining of human lung cancer using 11407-1-AP (same clone as 11407-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11407-1-AP (TACC2 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11407-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

11407-1-PBS bindet in WB, IHC, Indirect ELISA TACC2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TACC2 fusion protein Ag1923
Vollständiger Name transforming, acidic coiled-coil containing protein 2
Berechnetes Molekulargewicht 2948 aa, 309 kDa
Beobachtetes Molekulargewicht 73 kDa
GenBank-ZugangsnummerBC015736
Gene symbol TACC2
Gene ID (NCBI) 10579
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Transforming acidic coiled-coil (TACC) proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. TACC2, also known as anti-zuai-1 (AZU-1), was abundantly expressed in non- and premalignant cells and tissues but was appreciably reduced in breast tumor cell types and in primary tumors, thus TACC2 may act as a tumor suppressor protein and represent a tumor progression marker. Several transcript variants encoding different isoforms have been found for this gene. Chromosome segregation in mitosis is orchestrated by dynamic interaction between spindle microtubule and the kinetochore. Centrosomal TACC2 plays a role in organizing centrosomal microtubules and is required for mitotic spindle maintenance.