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TANC2 Polyklonaler Antikörper

TANC2 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31541-1-PBS

Synonyme

ROLSA, rols, KIAA1636, KIAA1148

Filter:
  • Western Blot (WB) analysis of various lysates using TANC2 Polyclonal antibody (31541-1-AP)

    WB analysis using 31541-1-AP (same clone as 31541-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31541-1-AP (TANC2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31541-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using TANC2 Polyclonal antibody (31541-1-AP)

    IF Staining of HeLa using 31541-1-AP (same clone as 31541-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using TANC2 antibody (31541-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 31541-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31541-1-PBS bindet in WB, IF/ICC, Indirect ELISA TANC2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TANC2 fusion protein Ag35427
Vollständiger Name tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Berechnetes Molekulargewicht219kDa
Beobachtetes Molekulargewicht220 kDa
GenBank-ZugangsnummerNM_001394998
Gene symbol TANC2
Gene ID (NCBI) 26115
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Tetratricopeptide repeat, ankyrin repeat, and coiled-coil containing 2 (TANC2), also known as KIAA1148 and KIAA1636, belongs to the TANC family. TANC2 is a large 220 kDa protein consisting of 1990 amino acid residues. Named after its domain architecture, it comprises tetratricopeptide (TPR) and ankyrin repeats (ANK), a coiled-coil domain, and a C-terminal PDZ-interacting motif. TANC2 is widely expressed in the developing human (in excitatory neurons and radial glial cells) and rodent brain as well as in the adult brain as a scaffold in the postsynaptic density (PSD) of excitatory neurons. As such, it facilitates cell signaling downstream of cell surface glutamate receptors through multi-protein complex formation with other PSD proteins (e.g. PSD95, SHANK1), influencing dendritic spine formation and synaptic strength (PMID: 33976205, 34964047).