TCF7L1/TCF7L2 Monoklonaler Antikörper

TCF7L1/TCF7L2 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2B2D12

Kat-Nr. : 67652-1-PBS

Synonyme

HMG box transcription factor 3, HMG box transcription factor 4, TCF 3, TCF 4, TCF3, TCF4, TCF7L1, TCF7L2, Transcription factor 7 like 1

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  WB analysis using 67652-1-Ig (same clone as 67652-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67652-1-Ig (TCF7L1/TCF7L2 antibody) at dilution of 1:50000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67652-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

67652-1-PBS bindet in WB, Indirect ELISA TCF7L1/TCF7L2 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Maus / IgG2b
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: TCF7L1/TCF7L2 fusion protein Ag28954
• Vollständiger Name: transcription factor 7-like 1 (T-cell specific, HMG-box)
• Berechnetes Molekulargewicht: 63 kDa
• Beobachtetes Molekulargewicht: 70 kDa
• GenBank-Zugangsnummer: BC058894
• Gene symbol: TCF7L1
• Gene ID (NCBI): 83439
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. This antibody raised against 1-200aa of human TCF7L1 can also react with TCF7L2.