TCTN3 Polyklonaler Antikörper

TCTN3 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16085-1-PBS

Synonyme

TECT3, TCTN 3, PSEC0041, OFD4, JBTS18

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  WB analysis using 16085-1-AP (same clone as 16085-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16085-1-AP (TCTN3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IP experiment of Hela cells using 16085-1-AP (same clone as 16085-1-PBS)

  IP result of anti-TCTN3 (16085-1-AP for IP and Detection). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung using 16085-1-AP (same clone as 16085-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung using 16085-1-AP (TCTN3 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung using 16085-1-AP (same clone as 16085-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung using 16085-1-AP (TCTN3 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

16085-1-PBS bindet in WB, IHC, Indirect ELISA TCTN3 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TCTN3 fusion protein Ag9084
• Vollständiger Name: tectonic family member 3
• Berechnetes Molekulargewicht: 607 aa, 66 kDa
• Beobachtetes Molekulargewicht: 66 kDa
• GenBank-Zugangsnummer: BC009494
• Gene symbol: TCTN3
• Gene ID (NCBI): 26123
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TCTN3 (tectonic-3 or TECT3) is a type I membrane protein that belongs to the tectonic family, which consists of TCTN1, TCTN2 and TCTN3. Studies in mice suggest that tectonic may be involved in Hedgehog (Hh) signaling, and essential for ciliogenesis. Tectonic is component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. TCTN3 is necessary for transduction of the sonic hedgehog (SHH) signaling pathway. Orofaciodigital syndromes (OFDSs) consist of a group of heterogeneous disorders characterized by abnormalities in the oral cavity, face, and digits and associated phenotypic abnormalities. Recently, TCTN3 mutations are found as the cause of an extreme form of OFD associated with bone dysplasia, tibial defect, cystic kidneys, and brain anomalies.