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TDO2 Rekombinanter Antikörper

TDO2 Rekombinant Antikörper für WB, Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Ratte

Anwendung

WB, Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

240068C2

Kat-Nr. : 83236-2-PBS

Synonyme

240068C2, EC:1.13.11.11, TDO, TO, TPH2

Filter:
  • Western Blot (WB) analysis of rat liver tissue using TDO2 Recombinant antibody (83236-2-RR)

    WB analysis of rat liver using 83236-2-RR (same clone as 83236-2-PBS)

    rat liver tissue were subjected to SDS PAGE followed by western blot with 83236-2-RR (TDO2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83236-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83236-2-RR

    Affinity and Kinetic Characterization of 83236-2-RR

    Biolayer interferometry (BLl) kinetic assays of 83236-2-RR against Human TDO2 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

83236-2-PBS bindet in WB, Cytometric bead array, Indirect ELISA TDO2 und zeigt Reaktivität mit human, Ratten

Getestete Reaktivität human, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TDO2 fusion protein Ag8531
Vollständiger Name tryptophan 2,3-dioxygenase
Berechnetes Molekulargewicht 406 aa, 48 kDa
Beobachtetes Molekulargewicht 40-50 kDa
GenBank-ZugangsnummerBC005355
Gene symbol TDO2
Gene ID (NCBI) 6999
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TDO2 (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 are three enzymes that catalyze the amino acid tryptophan into kynurenine in the kynurenine pathway (PMID: 23090118, 28469468). TDO2 plays an important role in neurological diseases such as Alzheimer's disease, Parkinson's disease and autism. Overexpression of TDO2 promoted tumor cell survival and was correlated with tumor grade and poor prognosis in triple negative breast cancer, brain tumors and esophageal squamous cell carcinoma. TDO2 may be a potential therapeutic target in some cancers. (PMID: 21976023, 30134247)