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TDP-43 Polyklonaler Antikörper

TDP-43 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27841-1-AP

Synonyme

ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43

Galerie der Validierungsdaten

Geprüfte Anwendungen

Empfohlene Verdünnung

AnwendungVerdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

27841-1-AP bindet in ELISA TDP-43 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TDP-43 fusion protein Ag26155
Vollständiger Name TAR DNA binding protein
Berechnetes Molekulargewicht 43 kDa
Beobachtetes Molekulargewicht 37-40 kDa
GenBank-ZugangsnummerBC001487
Gene symbol TARDBP
Gene ID (NCBI) 23435
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TDP-43 is a DNA and RNA-binding protein which regulates transcription and splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP-43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat and stabilize the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Besides, it may also be involved in microRNA biogenesis, apoptosis and cell division. 27841-1-AP is a rabbit polyclonal antibody recognises the 37-40 kDa protein because of the cleaved fragments and posttranslationally modification.