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TFAP2A,AP-2 Monoklonaler Antikörper

TFAP2A,AP-2 Monoklonal Antikörper für

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human, Maus, Ratte

Anwendung

Konjugation

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

1B12F11

Kat-Nr. : CL488-67076

Synonyme

TFAP2A, AP-2, AP2, AP 2alpha, AP 2

Geprüfte Anwendungen

Produktinformation

CL488-67076 bindet in TFAP2A,AP-2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen TFAP2A,AP-2 fusion protein Ag4112
Vollständiger Name transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Berechnetes Molekulargewicht 431 aa, 47 kDa
Beobachtetes Molekulargewicht 47 kDa
GenBank-ZugangsnummerBC017754
Gene symbol TFAP2A/AP-2
Gene ID (NCBI) 7020
Konjugation CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission maxima wavelengths493 nm / 522 nm
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
LagerungsbedingungenBei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The activator protein-2 (AP-2) family of transcription factors comprises five 52-kDa isoforms (AP-2α, AP-2β, AP-2γ, AP-2δ, and AP-2ε), which share a common structure: a proline/glutamine-rich transactivation domain in the N-terminal region and a helix-span-helix domain in the C-terminal region, which mediates dimerization and site-specific DNA binding. Depending on the cellular context, the AP-2 transcription factors are individually associated either with cell differentiation and development or with cancer progression/regression. [PMID:21966377] TFAP2A (AP-2-alpha) is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation [PMID:11694877]