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TGFBR3-Specific Polyklonaler Antikörper

TGFBR3-Specific Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20000-1-PBS

Synonyme

TGFBR3, betaglycan, BGCAN, TGF beta receptor type 3, TGF beta receptor type III

Filter:
  • Western Blot (WB) analysis of A549 cells using TGFBR3-Specific Polyclonal antibody (20000-1-AP)

    WB analysis of A549 using 20000-1-AP (same clone as 20000-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 20000-1-AP (TGFBR3-Specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20000-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A431 cells using TGFBR3-Specific Polyclonal antibody (20000-1-AP)

    WB analysis of A431 using 20000-1-AP (same clone as 20000-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 20000-1-AP (TGFBR3-Specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20000-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

20000-1-PBS bindet in WB, Indirect ELISA TGFBR3-Specific und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name transforming growth factor, beta receptor III
Berechnetes Molekulargewicht 93 kDa
Beobachtetes Molekulargewicht 110-150 kDa
GenBank-ZugangsnummerNM_003243
Gene symbol TGFBR3
Gene ID (NCBI) 7049
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Transforming growth factor β (TGF-β) is a multifunctional cytokine that plays important roles in normal development and homeostasis (PMID: 8530052). There are three TGF-β forms: TGF-β1, TGF-β2, and TGF-β3. The diverse effects of TGF-β are mediated by the TGF-β receptors and cell surface-binding proteins. Three TGF-beta receptors exist: TGFBR1, TFGBR2, TGFBR3 (PMID: 8530052; 30184463). TGFBR3, also known as betaglycan, is a transmembrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. In addition to the transmembrane form, the extracellular domain of TGFBR3 can be cleaved to a soluble form (sTGFBR3), which may serve as an antagonist of TGF-β to inhibit TGF-β signaling (PMID: 30184463). TGFBR3 has a larger apparent molecular weight than the calculated molecular weight, due to extensive carbohydrate modifications (PMID: 1556106). This antibody is specific to TGFBR3.