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TGM3 Polyklonaler Antikörper

TGM3 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21406-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using TGM3 Polyclonal antibody (21406-1-AP)

    WB analysis using 21406-1-AP (same clone as 21406-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21406-1-AP (TGM3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21406-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

21406-1-PBS bindet in WB, Indirect ELISA TGM3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TGM3 fusion protein Ag16131
Vollständiger Name transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Berechnetes Molekulargewicht 693 aa, 77 kDa
Beobachtetes Molekulargewicht77 kDa; 30-35 kDa; 44-50 kDa
GenBank-ZugangsnummerBC109076
Gene symbol TGM3
Gene ID (NCBI) 7053
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TGM3 (Transglutaminase 3) is a Protein Coding gene. Diseases associated with TGM3 include Uncombable Hair Syndrome 2 and Uncombable Hair Syndrome 1. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. TG3 is expressed as an inactive 77 kDa zymogen which must be activated by limited proteolytic processing into two fragments (44 kDa and 30 kDa) of which the larger, N-terminal fragment carries the catalytic activity (PMID: 35328331).