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TIGIT Rekombinanter Antikörper

TIGIT Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240423C7

Kat-Nr. : 98023-2-PBS

Synonyme

240423C7, T-cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3

Filter:
  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human TIGIT Rabbit Recombinant Antibody (98023-2-RR)

    FC experiment of human PBMCs using 98023-2-RR (same clone as 98023-2-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human TIGIT Rabbit Recombinant Antibody (98023-2-RR, Clone: 240423C7) or Isotype Control, and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with APC Anti-Human CD45RO. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98023-2-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human TIGIT Rabbit Recombinant Antibody (98023-2-RR)

    FC experiment of human PBMCs using 98023-2-RR (same clone as 98023-2-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human TIGIT Rabbit Recombinant Antibody (98023-2-RR, Clone: 240423C7) (red) or Isotype Control (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98023-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98023-2-RR

    Affinity and Kinetic Characterization of 98023-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98023-2-RR against Human TIGIT were performed. The affinity constant is 5.45 nM.

Geprüfte Anwendungen

Produktinformation

98023-2-PBS bindet in FC TIGIT und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name T cell immunoreceptor with Ig and ITIM domains
Berechnetes Molekulargewicht26 kDa
GenBank-ZugangsnummerNM_173799.4
Gene symbol TIGIT
Gene ID (NCBI) 201633
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499).