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TIGIT Rekombinanter Antikörper

TIGIT Rekombinant Antikörper für Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

240423A7

Kat-Nr. : 98023-3-PBS

Synonyme

240423A7, T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, VSIG9

Filter:
  • Affinity and Kinetic Characterization of 98023-3-RR

    Affinity and Kinetic Characterization of 98023-3-RR

    Biolayer interferometry (BLl) kinetic assays of 98023-3-RR against Human TIGIT were performed. The affinity constant is 4.00 nM.

Geprüfte Anwendungen

Produktinformation

98023-3-PBS bindet in Cytometric bead array, Indirect ELISA TIGIT und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TIGIT fusion protein Eg0749
Vollständiger Name T cell immunoreceptor with Ig and ITIM domains
Berechnetes Molekulargewicht26 kDa
GenBank-ZugangsnummerNM_173799.4
Gene symbol TIGIT
Gene ID (NCBI) 201633
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499).