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TIGIT Rekombinanter Antikörper

TIGIT Rekombinant Antikörper für

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

Konjugation

Unkonjugiert

CloneNo.

240423A7

Kat-Nr. : 98023-3-RR

Synonyme

VSTM3, VSIG9, V-set and transmembrane domain-containing protein 3, V-set and immunoglobulin domain-containing protein 9, T-cell immunoreceptor with Ig and ITIM domains

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  • Affinity and Kinetic Characterization of 98023-3-RR

    Affinity and Kinetic Characterization of 98023-3-RR

    Biolayer interferometry (BLl) kinetic assays of 98023-3-RR against Human TIGIT were performed. The affinity constant is 4.00 nM.

Geprüfte Anwendungen

Produktinformation

98023-3-RR bindet in TIGIT und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Fusionsprotein
Vollständiger Name T cell immunoreceptor with Ig and ITIM domains
Berechnetes Molekulargewicht26 kDa
GenBank-ZugangsnummerNM_173799.4
Gene symbol TIGIT
Gene ID (NCBI) 201633
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS with 0.09% sodium azide
LagerungsbedingungenStore at 2-8°C. Stable for one year after shipment.

Hintergrundinformationen

TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499).