KIM-1/HAVCR1 Rekombinanter Antikörper

KIM-1/HAVCR1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242001D1

Kat-Nr. : 84600-5-PBS

Synonyme

HAVCR1, KIM-1, TIM-1, 242001D1, CD365

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  WB analysis of HuH-7 using 84600-5-RR (same clone as 84600-5-PBS)

  HuH-7 cells were subjected to SDS PAGE followed by western blot with 84600-5-RR (TIM-1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84600-5-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 84600-5-RR

  Biolayer interferometry (BLl) kinetic assays of 84600-5-RR against Human TIM-1 were performed. The affinity constant is 0.314 nM.

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Geprüfte Anwendungen

Produktinformation

84600-5-PBS bindet in WB, Indirect ELISA KIM-1/HAVCR1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: KIM-1/HAVCR1 fusion protein Eg1442
• Vollständiger Name: hepatitis A virus cellular receptor 1
• Berechnetes Molekulargewicht: 39kDa
• Beobachtetes Molekulargewicht: 100 kDa
• GenBank-Zugangsnummer: NM_001173393.3
• Gene symbol: HAVCR1
• Gene ID (NCBI): 26762
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TIM-1, also known as kidney injury molecule (KIM-1), was first identified as a marker of acute kidney injury. TIM-1 mRNA and protein dramatically increase after ischemic kidney injury while there are low levels in normal kidneys. In addition, TIM-1 is expressed on CD4+ T cells after activation and its expression was sustained preferentially in Th2 but not Th1 cells. However, TIM-1 is expressed on both Th1 and Th2 cells and TIM-1 blockade prolongs survival of fully MHC-mismatched cardiac transplants. TIM-4, expressed by macrophages, is the ligand for TIM-1, and TIM-1 - TIM-4 interactions regulate Th cell responses and modulate Th1/Th2 cytokine balance. Moreover, TIM-1 can regulate macrophage activation and alter the co-stimulatory properties of macrophages. (PMID: 20091883)