TIM3 Rekombinanter Antikörper
TIM3 Rekombinant Antikörper für FC
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
FC
Konjugation
CoraLite®594 Fluorescent Dye
CloneNo.
241422H1
Kat-Nr. : CL594-98115
Synonyme
Geprüfte Anwendungen
Erfolgreiche Detektion in FC | Anti-CD3/CD28 treated human PBMCs |
Empfohlene Verdünnung
Anwendung | Verdünnung |
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This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood. | |
Sample-dependent, check data in validation data gallery |
Produktinformation
CL594-98115 bindet in FC TIM3 und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Rekombinant |
Typ | Antikörper |
Immunogen | Rekombinantes Protein |
Vollständiger Name | hepatitis A virus cellular receptor 2 |
Berechnetes Molekulargewicht | 301 aa, 33 kDa |
GenBank-Zugangsnummer | BC020843 |
Gene symbol | TIM3 |
Gene ID (NCBI) | 84868 |
Konjugation | CoraLite®594 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 588 nm / 604 nm |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS with 0.09% sodium azide and 0.5% BSA |
Lagerungsbedingungen | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Hintergrundinformationen
TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920).
Protokolle
PRODUKTSPEZIFISCHE PROTOKOLLE | |
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FC protocol for CL594 TIM3 antibody CL594-98115 | Download protocol |
STANDARD-PROTOKOLLE | |
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Klicken Sie hier, um unsere Standardprotokolle anzuzeigen |