TIMP2 Rekombinanter Antikörper

TIMP2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243160E10

Kat-Nr. : 83938-3-PBS

Synonyme

TIMP-2, CSC 21K, CSC-21K, Metalloproteinase inhibitor 2, TIMP 2

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  WB analysis using 83938-3-RR (same clone as 83938-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83938-3-RR (TIMP2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83938-3-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

83938-3-PBS bindet in WB, Indirect ELISA TIMP2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: TIMP2 fusion protein Eg0430
• Vollständiger Name: TIMP metallopeptidase inhibitor 2
• Berechnetes Molekulargewicht: 220 aa, 24 kDa
• Beobachtetes Molekulargewicht: 21-24 kDa
• GenBank-Zugangsnummer: BC052605
• Gene symbol: TIMP2
• Gene ID (NCBI): 7077
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The TIMPs are natural highly specific endogenous inhibitors of MMPs. Human TIMP family consists of four 21-28 kDa proteins known as TIMP1, TIMP2, TIMP3, and TIMP4 encoded by four paralogous genes.TIMPs are vital to the maintenance of ECM homeostasis primarily through their MMP inhibitory functions. TIMP2, a member of the TIMP family, regulates the proteolytic activity of all MMPs and is involved in cell differentiation, growth, migration, angiogenesis, and apoptosis. Urinary TIMP2 has been recently recognized as an early biomarker to predict Acute kidney injury (AKI) in critically ill patients.