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TLE3 Rekombinanter Antikörper

TLE3 Rekombinant Antikörper für IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, ELISA

Konjugation

Unkonjugiert

CloneNo.

240680G3

Kat-Nr. : 83955-4-PBS

Synonyme

GRG3, GRG 3, ESG3, ESG, Enhancer of split groucho-like protein 3

Filter:
  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using TLE3 Recombinant antibody (83955-4-RR)

    IF Staining of HepG2 using 83955-4-RR (same clone as 83955-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using TLE3 antibody (83955-4-RR, Clone: 240680G3 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 83955-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83955-4-RR

    Affinity and Kinetic Characterization of 83955-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83955-4-RR against Human TLE3 were performed. The affinity constant is 0.134 nM.

Geprüfte Anwendungen

Produktinformation

83955-4-PBS bindet in IF/ICC, ELISA TLE3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TLE3 fusion protein Ag1930
Vollständiger Name transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
Berechnetes Molekulargewicht 772 aa, 83 kDa
GenBank-ZugangsnummerBC015729
Gene symbol TLE3
Gene ID (NCBI) 7090
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TLE3, also named as KIAA1547 and ESG3, belongs to the WD repeat Groucho/TLE family. It is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas. It is a candidate biomarker of response to taxane