TLR6 Polyklonaler Antikörper

• Featured Product
• KD/KO Validated

TLR6 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 22240-1-PBS

Synonyme

CD286, toll like receptor 6, Toll-like receptor 6

---

• 

  WB analysis of RAW 264.7 using 22240-1-AP (same clone as 22240-1-PBS)

  RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 22240-1-AP (TLR6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22240-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 22240-1-AP (same clone as 22240-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 22240-1-AP (TLR6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22240-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human brain using 22240-1-AP (same clone as 22240-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 22240-1-AP (TLR6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22240-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse thymus using 22240-1-AP (same clone as 22240-1-PBS)

  mouse thymus tissue were subjected to SDS PAGE followed by western blot with 22240-1-AP (TLR6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22240-1-PBS in a different storage buffer formulation.

• 

  WB analysis of Jurkat using 22240-1-AP (same clone as 22240-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 22240-1-AP (TLR6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22240-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HT-1080 using 22240-1-AP (same clone as 22240-1-PBS)

  HT-1080 cells were subjected to SDS PAGE followed by western blot with 22240-1-AP (TLR6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22240-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

22240-1-PBS bindet in WB, Indirect ELISA TLR6 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TLR6 fusion protein Ag17686
• Vollständiger Name: toll-like receptor 6
• Berechnetes Molekulargewicht: 480 aa, 56 kDa
• Beobachtetes Molekulargewicht: 95-110 kDa
• GenBank-Zugangsnummer: BC111755
• Gene symbol: TLR6
• Gene ID (NCBI): 10333
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TLR6, also known as CD286, belongs to the Toll-like receptor (TLR) family, which is important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLR6 can form a heterodimer with TLR2. TLR6 and TLR2 are recruited to the macrophage phagosome, where they recognize peptidoglycan, a Gram-positive pathogen component (PMID: 11095740). TLR6 interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers an inflammatory response.