TMEM106B Monoklonaler Antikörper

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• KD/KO Validated

TMEM106B Monoklonal Antikörper für WB, IP, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, IP, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

5D1F8

Kat-Nr. : 60333-1-PBS

Synonyme

TMEM106B (1-46aa), 5D1F8, Transmembrane protein 106B

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  WB analysis using 60333-1-Ig (same clone as 60333-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 60333-1-Ig (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 60333-1-Ig (same clone as 60333-1-PBS)

  WB result of TMEM106B antibody (60333-1-Ig; 1:2000; room temperature for 1.5 hours) with wild-type and TMEM106B knockout HeLa cells. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 60333-1-Ig (same clone as 60333-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 60333-1-Ig (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 60333-1-Ig (same clone as 60333-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 60333-1-Ig (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

• 

  IP experiment of HeLa using 60333-1-Ig (same clone as 60333-1-PBS)

  IP result of anti-TMEM106B (IP:60333-1-Ig, 5ug; Detection:60333-1-Ig 1:500) with HeLa cells lysate 1720 ug. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

60333-1-PBS bindet in WB, IP, Indirect ELISA TMEM106B und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: TMEM106B fusion protein Ag21448
• Vollständiger Name: transmembrane protein 106B
• Berechnetes Molekulargewicht: 31 kDa
• Beobachtetes Molekulargewicht: ~40 kDa
• GenBank-Zugangsnummer: BC033901
• Gene symbol: TMEM106B
• Gene ID (NCBI): 54664
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression.