TMEM106B Rekombinanter Antikörper

TMEM106B Rekombinant Antikörper für WB, IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

CloneNo.

241185F10

Kat-Nr. : 84196-2-PBS

Synonyme

241185F10, Transmembrane protein 106B

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  WB analysis using 84196-2-RR (same clone as 84196-2-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84196-2-RR (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84196-2-PBS in a different storage buffer formulation.

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  IHC staining of mouse cerebellum using 84196-2-RR (same clone as 84196-2-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 84196-2-RR (TMEM106B antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84196-2-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse cerebellum using 84196-2-RR (same clone as 84196-2-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 84196-2-RR (TMEM106B antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84196-2-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

84196-2-PBS bindet in WB, IHC, ELISA TMEM106B und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: transmembrane protein 106B
• Berechnetes Molekulargewicht: 31 kDa
• Beobachtetes Molekulargewicht: 35 kDa
• GenBank-Zugangsnummer: BC033901
• Gene symbol: TMEM106B
• Gene ID (NCBI): 54664
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. TMEM106B can be showed as 31-55 kDa and 70-90 kDa (Glycosylated or Dimer) form in western blot test. (PMID: 27543298, 22895706, PMID: 23136129).