TMEM176B Polyklonaler Antikörper

TMEM176B Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen

2

Kat-Nr. : 19825-1-AP

Synonyme

LR8, Protein LR8, TMEM176B, transmembrane protein 176B

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Galerie der Validierungsdaten

• 

  WB analysis of A549 using 19825-1-AP

  A549 cells were subjected to SDS PAGE followed by western blot with 19825-1-AP (TMEM176B Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  WB analysis of A549 using 19825-1-AP

  A549 cells were subjected to SDS PAGE followed by western blot with 19825-1-AP (TMEM176B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of human placenta using 19825-1-AP

  human placenta tissue were subjected to SDS PAGE followed by western blot with 19825-1-AP (TMEM176B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: A549-Zellen, humanes Plazenta-Gewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 1 publications below

Produktinformation

19825-1-AP bindet in WB, ELISA TMEM176B und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TMEM176B fusion protein Ag13918
• Vollständiger Name: transmembrane protein 176B
• Berechnetes Molekulargewicht: 270 aa, 29 kDa
• Beobachtetes Molekulargewicht: 31 kDa, 23 kDa
• GenBank-Zugangsnummer: BC004358
• Gene symbol: TMEM176B
• Gene ID (NCBI): 28959
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TMEM176B (also known as LR8) is a transmembrane protein belongs to the MS4A family of proteins. It may play a role in the process of maturation of dendritic cells. TMEM176B was first discovered in human lung fibroblasts and is associated with human small cell lung carcinoma. Studies suggest that TMEM176B might be involved in cancer and might serve as targets for antiangiogenic therapy of cancer patients (PMID: 24602018, 22244448). There are two isoforms produced by alternative splicing.

Publikationen

Species	Application	Title
human	WB	Front Genet; Comprehensive Analysis of Expression and Prognostic Value of MS4As in Glioma.; Authors - Yingying Zeng
		Cancer Cell; Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.; Authors - Mercedes Segovia