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TMEM43 Polyklonaler Antikörper

TMEM43 Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16362-1-PBS

Synonyme

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  • Immunohistochemistry (IHC) staining of mouse heart tissue using TMEM43 Polyclonal antibody (16362-1-AP)

    IHC staining of mouse heart using 16362-1-AP (same clone as 16362-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 16362-1-AP (TMEM43 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16362-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

16362-1-PBS bindet in IHC, Indirect ELISA TMEM43 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TMEM43 fusion protein Ag8522
Vollständiger Name transmembrane protein 43
Berechnetes Molekulargewicht 400 aa, 45 kDa
GenBank-ZugangsnummerBC008054
Gene symbol TMEM43
Gene ID (NCBI) 79188
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Transmembrane protein 43 (TMEM43), a member of the TMEM subfamily, is encoded by a highly conserved gene and is widely expressed in most species, ranging from bacteria to humans. The TMEM43 S358L mutation on chromosome 3p25 is an important cause of arrhythmogenic right ventricular cardiomyopathy (ARVC) as it enhances the NF-κB-TGFβ signal cascade, which can lead to aggressive disease at the early stage, and might later develop into heart disease. (PMID: 35260078)