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TMIGD2/CD28H Rekombinanter Antikörper

TMIGD2/CD28H Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Hausschwein, human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241807C12

Kat-Nr. : 84727-5-PBS

Synonyme

TMIGD2/CD28, Immunoglobulin and proline-rich receptor 1, IGPR-1, IGPR1, CD28H

Filter:
  • Western Blot (WB) analysis of various lysates using TMIGD2/CD28H Recombinant antibody (84727-5-RR)

    WB analysis using 84727-5-RR (same clone as 84727-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84727-5-RR (TMIGD2/CD28H antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84727-5-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of pig thymus tissue using TMIGD2/CD28H Recombinant antibody (84727-5-RR)

    WB analysis of pig thymus using 84727-5-RR (same clone as 84727-5-PBS)

    pig thymus tissue were subjected to SDS PAGE followed by western blot with 84727-5-RR (TMIGD2/CD28H antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84727-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84727-5-RR

    Affinity and Kinetic Characterization of 84727-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84727-5-RR against Human TMIGD2/CD28H were performed. The affinity constant is 1.23 nM.

Geprüfte Anwendungen

Produktinformation

84727-5-PBS bindet in WB, Indirect ELISA TMIGD2/CD28H und zeigt Reaktivität mit Hausschwein, human

Getestete Reaktivität Hausschwein, human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name transmembrane and immunoglobulin domain containing 2
Berechnetes Molekulargewicht 282 aa, 31 kDa
Beobachtetes Molekulargewicht48 kDa
GenBank-ZugangsnummerBC015655
Gene symbol TMIGD2
Gene ID (NCBI) 126259
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2, also known as CD28H and IGPR1), plays a role in cell-cell interaction, migration, and angiogenesis. Through interaction with HHLA2, it costimulates T-cells in the context of TCR-mediated activation and enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade (PMID: 22419821; 23784006). TMIGD2 has been associated with several diseases, particularly in the context of cancer. It is aberrantly expressed by human AML cells and can be used to identify and enrich functional LSCs (PMID: 38167704). The predicted molecular weight of the TMIGD2 protein is 31 kDa. The higher molecular weight of TMIGD2 could be associated with its potential glycosylation at its extracellular region (PMID: 22419821).