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TMPRSS2 Rekombinanter Antikörper

TMPRSS2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

7I5

Kat-Nr. : 80152-1-PBS

Synonyme

FLJ41954, PP9284, PRSS10, Serine protease 10, TMPRSS2

Filter:
  • Western Blot (WB) analysis of various lysates using TMPRSS2 Recombinant antibody (80152-1-RR)

    WB analysis using 80152-1-RR (same clone as 80152-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 80152-1-RR (TMPRSS2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80152-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

80152-1-PBS bindet in WB, Indirect ELISA TMPRSS2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TMPRSS2 fusion protein Ag5824
Vollständiger Name transmembrane protease, serine 2
Berechnetes Molekulargewicht 54 kDa
Beobachtetes Molekulargewicht55 kDa
GenBank-ZugangsnummerBC051839
Gene symbol TMPRSS2
Gene ID (NCBI) 7113
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TMPRSS2, also named as PRSS10, is a type II transmembrane serine protease which is highly expressed by the epithelium of the human prostate gland. TMPRSS2 may contribute to prostate tumor metastasis via the activation of PAR-2. TMPRSS2 is a Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. TMPRSS2 as a host cell factor that is critical for spread of several clinically relevant viruses, including influenza A viruses and coronaviruses (PMID: 23468491, 30626688). SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. The initial spike protein priming by TMPRSS2 is essential for entry and viral spread of SARS-CoV-2 through interaction with the ACE2 receptor (PMID: 32142651, 30626688 ). Camostat mesylate, an inhibitor of TMPRSS2, can block SARS-CoV-2 infection of lung cells (PMID: 32142651). The MW of TMPRSS2 is about 65-70 kDa. It can be cleaved into some chains with MW 54 kDa, 31 kDa and 26 kDa (PMID: 25734995, 20382709, 26018085).