TMPRSS4 Polyklonaler Antikörper

• Featured Product
• KD/KO Validated

TMPRSS4 Polyklonal Antikörper für IHC, WB,ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

20

Kat-Nr. : 11283-1-AP

Synonyme

CAPH2, Channel activating protease 2, MT SP2, TMPRSS3, TMPRSS4

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Galerie der Validierungsdaten

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  WB analysis of SW 1990 using 11283-1-AP

  SW 1990 cells were subjected to SDS PAGE followed by western blot with 11283-1-AP (TMPRSS4 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

• 

  WB analysis of SW 1990 using 11283-1-AP

  SW 1990 cells were subjected to SDS PAGE followed by western blot with 11283-1-AP (TMPRSS4 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse stomach using 11283-1-AP

  mouse stomach tissue were subjected to SDS PAGE followed by western blot with 11283-1-AP (TMPRSS4 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis of BxPC-3 using 11283-1-AP

  BxPC-3 cells were subjected to SDS PAGE followed by western blot with 11283-1-AP (TMPRSS4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  IHC staining of human pancreas cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 11283-1-AP (TMPRSS4 Antibody) at dilution of 1:200 (under 40x lens).

• 

  IHC staining of human pancreas cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 11283-1-AP (TMPRSS4 Antibody) at dilution of 1:200 (under 10x lens).

• 

  IHC staining of human pancreas cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human stomach cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human stomach cancer using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human stomach cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human stomach cancer using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human colon cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human colon cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human pancreas cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human pancreas cancer using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human colon using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human colon using 11283-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon using 11283-1-AP (TMPRSS4 antibody) at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: SW 1990-Zellen, BxPC-3-Zellen, Maus-Magengewebe
• Erfolgreiche Detektion in IHC: humanes Pankreaskarzinomgewebe, humanes Kolongewebe, humanes Kolonkarzinomgewebe, humanes Magenkrebsgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:2000
• Immunhistochemie (IHC): IHC : 1:100-1:400

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 3 publications below
• WB: See 13 publications below
• IHC: See 12 publications below
• IF: See 3 publications below

Produktinformation

11283-1-AP bindet in WB, IHC, IF, ELISA TMPRSS4 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TMPRSS4 fusion protein Ag1804
• Vollständiger Name: transmembrane protease, serine 4
• Berechnetes Molekulargewicht: 48 kDa
• Beobachtetes Molekulargewicht: 55 kDa
• GenBank-Zugangsnummer: BC011703
• Gene symbol: TMPRSS4
• Gene ID (NCBI): 56649
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TMPRSS4, also named as CAPH2 and MT-SP2, belongs to the peptidase S1 family. TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed on the cell surface in pancreatic, thyroid and other cancer tissues. It promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition(EMT)(PMID:20118200).

Publikationen

Species	Application	Title
human	WB	Gastroenterology; Angiotensin-converting Enzyme 2-containing Extracellular Vesicles and Exomeres Bind the Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein.; Authors - Qin Zhang
human	WB	Cancer Res; TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation.; Authors - David J Drasin
mouse	WB	Int J Mol Sci; Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19.; Authors - Samar Rezq
human	WB,IHC,IF	Carcinogenesis; TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways.; Authors - Kim Semi S
human, mouse	WB, IHC, IF	Cancer Lett; TMPRSS4 induces cancer stem cell-like properties in lung cancer cells and correlates with ALDH expression in NSCLC patients.; Authors - Arrate L de Aberasturi
human	IHC	Front Immunol; TSPAN1, TMPRSS4, SDR16C5, and CTSE as Novel Panel for Pancreatic Cancer: A Bioinformatics Analysis and Experiments Validation.; Authors - Hua Ye

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