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TMUB1 Polyklonaler Antikörper

TMUB1 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16638-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using TMUB1 Polyclonal antibody (16638-1-AP)

    WB analysis using 16638-1-AP (same clone as 16638-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16638-1-AP (TMUB1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16638-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of L02 cells using TMUB1 Polyclonal antibody (16638-1-AP)

    IF Staining of L02 using 16638-1-AP (same clone as 16638-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed L02 cells using TMUB1 antibody (16638-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 16638-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

16638-1-PBS bindet in WB, IF/ICC, Indirect ELISA TMUB1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TMUB1 fusion protein Ag9988
Vollständiger Name transmembrane and ubiquitin-like domain containing 1
Berechnetes Molekulargewicht 26 kDa
Beobachtetes Molekulargewicht27 kDa, 24 kDa
GenBank-ZugangsnummerBC000936
Gene symbol TMUB1
Gene ID (NCBI) 83590
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1), also referred to as hepatocyte odd protein shuttling (HOPS), is a transmembrane ubiquitin-like protein that was originally identified in the regenerated liver. HOPS is a transmembrane protein released into the cell by an enzymatic cleavage. This allows HOPS to be shuttled from the nucleus to the cytoplasm and vice versa, depending on cell cycle and environmental stress conditions. HOPS cDNA expression gives rise to the translation of three different proteins with distinct molecular weights of 27, 24 and 21 kDa, respectively.The three isoforms of HOPS are differentially expressed depending on the tissue being examined. In the brain, the shortest isoform prevails over the other, whereas in the intestine the higher molecular weight isoform prevails among the other two. Indeed, HOPS shows a different concentration of the three isoforms, which can play different cell-dependent functions. The ratio between different isoforms may vary owing to physiopathological changes in the cell (PMID:32860479).16638-1-AP can detect two bands and some literature also detected two bands (PMID:30610893, 29777440, 29967478)