TNFAIP8 Polyklonaler Antikörper

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• KD/KO Validated

TNFAIP8 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 15790-1-PBS

Synonyme

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  WB analysis using 15790-1-AP (same clone as 15790-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 15790-1-AP (TNFAIP8 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15790-1-PBS in a different storage buffer formulation.

• 

  WB analysis of A549 using 15790-1-AP (same clone as 15790-1-PBS)

  A549 cells were subjected to SDS PAGE followed by western blot with 15790-1-AP (TNFAIP8 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15790-1-PBS in a different storage buffer formulation.

• 

  WB analysis of PC-13 using 15790-1-AP (same clone as 15790-1-PBS)

  PC-13 cells were subjected to SDS PAGE followed by western blot with 15790-1-AP (TNFAIP8 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15790-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human tonsillitis using 15790-1-AP (same clone as 15790-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis slide using 15790-1-AP (TNFAIP8 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 15790-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lung cancer using 15790-1-AP (same clone as 15790-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung cancer slide using 15790-1-AP (TNFAIP8 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 15790-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human tonsillitis using 15790-1-AP (same clone as 15790-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis slide using 15790-1-AP (TNFAIP8 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 15790-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lung cancer using 15790-1-AP (same clone as 15790-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung cancer slide using 15790-1-AP (TNFAIP8 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 15790-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

15790-1-PBS bindet in WB, IHC, Indirect ELISA TNFAIP8 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TNFAIP8 fusion protein Ag8491
• Vollständiger Name: tumor necrosis factor, alpha-induced protein 8
• Berechnetes Molekulargewicht: 198 aa, 23 kDa
• Beobachtetes Molekulargewicht: 19-23 kDa
• GenBank-Zugangsnummer: BC007014
• Gene symbol: TNFAIP8
• Gene ID (NCBI): 25816
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TNFAIP8 (tumor necrosis factor, alpha-induced protein 8), also called SCC-S2/GG2-1/NDED, is associated with enhanced cell survival and inhibition of apoptosis. The induction of TNFAIP8 by TNF depends on the activation of NFκB. TNFAIP8 suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. TNFAIP8 is expressed in adult spleen, lymph node, thymus, thyroid, bone marrow, and placenta, and in fetal liver, lung, and kidney at high levels, also expressed in various tumor tissues and all cancer cell lines tested. There are four major isoforms of TNFAIP8.