TNFR2/CD120b Rekombinanter Antikörper
TNFR2/CD120b Rekombinant Antikörper für
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
Konjugation
Unkonjugiert
CloneNo.
230328B3
Kat-Nr. : 98010-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
98010-1-PBS bindet in TNFR2/CD120b und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Rekombinant |
| Typ | Antikörper |
| Immunogen | TNFR2/CD120b fusion protein Eg0086 |
| Vollständiger Name | tumor necrosis factor receptor superfamily, member 1B |
| Berechnetes Molekulargewicht | 48 kDa |
| GenBank-Zugangsnummer | BC052977 |
| Gene symbol | TNFR2 |
| Gene ID (NCBI) | 7133 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. Stable for one year after shipment. |
Hintergrundinformationen
Tumor necrosis factor-alpha (TNFA/TNFSF2) is a multifunctional cytokine that plays a key role in regulating inflammation, immune functions, host defense, and apoptosis (PMID: 16407280). TNFA signals through two distinct cell surface receptors, TNFR1 (TNFRSF1A, CD120a, p55) and TNFR2 (TNFRSF1B, CD120b, p75). TNFR1 is widely expressed, whereas TNFR2 exhibits more restricted expression, being found on CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes, neuron subtypes, cardiac myocytes, thymocytes and human mesenchymal stem cells (PMID: 20489699; 22374304). In contrast to TNFR1, TNFR2 does not have a death domain. TNFR2 only signals for antiapoptotic reactions. However, recent evidence indicates that TNFR2 also signals to induce TRAF2 degradation (PMID: 22374304). Various defects in the TNFR2 pathway, due to polymorphisms in the TNFR2 gene, upregulated expression of TNFR2 and TNFR2 shedding, have been implicated in the pathology of several autoimmune disorders (PMID: 20489699).
