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TNFR2/CD120b Rekombinanter Antikörper

TNFR2/CD120b Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

230328B6

Kat-Nr. : 98010-2-PBS

Synonyme

TNFRSF1B, p80 TNF alpha receptor, p75TNFR, p75, Etanercept

Filter:
  • Flow cytometry (FC) experiment of human peripheral blood leukocytes using Anti-Human TNFR2/CD120b Rabbit Recombinant Antibod (98010-2-RR)

    FC experiment of human peripheral blood leukocytes using 98010-2-RR (same clone as 98010-2-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human TNFR2/CD120b Rabbit Recombinant Antibody (98010-2-RR, Clone:230328B6) and PE-conjugated Goat Anti-Rabbit IgG, or 0.25 ug Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 98010-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98010-2-RR

    Affinity and Kinetic Characterization of 98010-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98010-2-RR against Human TNFR2/CD120b were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

98010-2-PBS bindet in FC TNFR2/CD120b und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name tumor necrosis factor receptor superfamily, member 1B
Berechnetes Molekulargewicht 48 kDa
GenBank-ZugangsnummerBC052977
Gene symbol TNFR2
Gene ID (NCBI) 7133
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

Tumor necrosis factor-alpha (TNFA/TNFSF2) is a multifunctional cytokine that plays a key role in regulating inflammation, immune functions, host defense, and apoptosis (PMID: 16407280). TNFA signals through two distinct cell surface receptors, TNFR1 (TNFRSF1A, CD120a, p55) and TNFR2 (TNFRSF1B, CD120b, p75). TNFR1 is widely expressed, whereas TNFR2 exhibits more restricted expression, being found on CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes, neuron subtypes, cardiac myocytes, thymocytes and human mesenchymal stem cells (PMID: 20489699; 22374304). In contrast to TNFR1, TNFR2 does not have a death domain. TNFR2 only signals for antiapoptotic reactions. However, recent evidence indicates that TNFR2 also signals to induce TRAF2 degradation (PMID: 22374304). Various defects in the TNFR2 pathway, due to polymorphisms in the TNFR2 gene, upregulated expression of TNFR2 and TNFR2 shedding, have been implicated in the pathology of several autoimmune disorders (PMID: 20489699).