CD268/BAFF-R Rekombinanter Antikörper

CD268/BAFF-R Rekombinant Antikörper für Sandwich ELISA, Indirect ELISA, Sample test

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

Sandwich ELISA, Indirect ELISA, Sample test

Konjugation

Unkonjugiert

CloneNo.

242003C5

Kat-Nr. : 84585-4-PBS

Synonyme

TNFRSF13C, B-cell-activating factor receptor, BAFF-R, BAFFR, BAFF receptor

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  Sandwich ELISA standard curve of MP01419-3

  Sandwich ELISA standard curve of MP01419-3, Human TNFRSF13C Recombinant Matched Antibody Pair - PBS only. 84585-4-PBS was coated to a plate as the capture antibody and incubated with serial dilutions of standard Eg1922. 84585-3-PBS was HRP conjugated as the detection antibody. Range: 0.156-10 ng/mL.

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  Sample test of MP01419-3

  Serum of six individual healthy human donors was measured. The TNFRSF13C concentration of detected samples was determined to be 0.64 ng/mL with a range of 0.27-0.85 ng/mL.

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  Affinity and Kinetic Characterization of 84585-4-PBS

  Biolayer interferometry (BLl) kinetic assay of 84585-4-PBS against Human TNFRSF13C was performed. The affinity constant is 3.96 nM.

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Geprüfte Anwendungen

Produktinformation

84585-4-PBS bindet in Sandwich ELISA, Indirect ELISA, Sample test CD268/BAFF-R und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 13C
• Berechnetes Molekulargewicht: 184 aa, 19 kDa
• GenBank-Zugangsnummer: BC105123
• Gene symbol: TNFRSF13C
• Gene ID (NCBI): 115650
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells (PMID: 32528875). The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation (PMID: 30349534). Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells (PMID: 38791453).