HVEM/TNFRSF14 Polyklonaler Antikörper

HVEM/TNFRSF14 Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (1)

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Publikationen(5)

Kat-Nr. : 10138-1-AP

Synonyme

ATAR, Herpes virus entry mediator A, Herpesvirus entry mediator A, HVEA, HVEM, LIGHTR, TNFRSF14, TR2

---

• 

  IHC staining of human spleen using 10138-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 10138-1-AP (HVEM/TNFRSF14 antibody at dilution of 1:200 (under 10x lens).

• 

  IHC staining of human spleen using 10138-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 10138-1-AP (HVEM/TNFRSF14 antibody at dilution of 1:200 (under 40x lens).

---

Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Milzgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 3 publications below
• IHC: See 2 publications below

Produktinformation

10138-1-AP bindet in WB, IHC, ELISA HVEM/TNFRSF14 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: HVEM/TNFRSF14 fusion protein Ag0186
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
• Berechnetes Molekulargewicht: 30 kDa
• GenBank-Zugangsnummer: BC002794
• Gene symbol: TNFRSF14
• Gene ID (NCBI): 8764
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The mammalian tumor necrosis factor receptor (TNFR) family consists of 10 cell-surface proteins that regulate development and homeostasis of the immune system. Member 14 of TNFR (TNFRSF14, also named as TR2, ATAR, HVEA, HVEM, LIGHTR) was also identified as a mediator of herpesvirus entry into mammalian cells. The cytoplasmic region of TNFRSF14 bound to several members of the TNFR-associated factor (TRAF) family, namely TRAF1, TRAF2, TRAF3, and TRAF5. Transient transfection into human 293 cells caused marked activation of nuclear factor- B (NF- B), a transcriptional regulator of multiple immunomodulatory and inflammatory genes.

Publikationen

Species	Application	Title
mouse	WB	Cancer Immunol Res; Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition.; Authors - Lin Xia
human	WB	Obesity (Silver Spring); Characterization of herpes virus entry mediator as a factor linked to obesity.; Authors - Judit Bassols
human	IHC	EBioMedicine; Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma.; Authors - Ming-Zhi Han
human	IHC	Dig Liver Dis; Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis; Authors - Sachiko Kanai
mouse	WB	Immun Inflamm Dis; Tumor Cell-Expressed Herpesvirus Entry Mediator Regulates Proliferation and Adaptive Immunity in Ovarian Cancer; Authors - Yun Lu ; KD Validated

{{ptg:RelatedPrimaryAntibodies}}