TNFRSF21/DR6 Rekombinanter Antikörper

TNFRSF21/DR6 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250249D8

Kat-Nr. : 98523-2-PBS

Synonyme

DR6, TNFRSF21, CD358, Death receptor 6, UNQ437/PRO868

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  FC experiment of A431 using 98523-2-RR (same clone as 98523-2-PBS)

  1x10^6 A431 cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98523-2-PBS in a different storage buffer formulation.

• 

  FC experiment of A431 using 98523-2-RR (same clone as 98523-2-PBS)

  1x10^6 A431 cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98523-2-PBS in a different storage buffer formulation.

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  FC experiment of Transfected CHO using 98523-2-RR (same clone as 98523-2-PBS)

  1x10^6 HEK-293T cells or TNFRSF21/DR6-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98523-2-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected CHO using 98523-2-RR (same clone as 98523-2-PBS)

  1x10^6 HEK-293T cells or TNFRSF21/DR6-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98523-2-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98523-2-PBS bindet in FC TNFRSF21/DR6 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: TNFRSF21/DR6 fusion protein Eg2718
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 21
• Berechnetes Molekulargewicht: 72 kDa
• GenBank-Zugangsnummer: NM_014452.5
• Gene symbol: DR6
• Gene ID (NCBI): 27242
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

TNFRSF21 (also known as DR6 or CD358) is an orphan receptor of the tumor necrosis factor (TNF) receptor superfamily. It controls cell death and differentiation in a cell-autonomous manner in different cell types including neurons, oligodendrocytes, endothelial cells, and immune cells (PMID: 29459438). DR6 has been shown to activate NF-κB and JNK, and induce cell apoptosis (PMID: 9714541). DR6 interacts with TRADD, which is known to mediate signal transduction of TNF receptors. It has been reported that APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, indicating that DR6 might be involved in Alzheimer's disease (PMID: 19225519).