TNFRSF21/DR6 Rekombinanter Antikörper

TNFRSF21/DR6 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250249D8

Kat-Nr. : 98523-2-RR

Synonyme

DR6, TNFRSF21, CD358, Death receptor 6, UNQ437/PRO868

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  FC experiment of A431 using 98523-2-RR

  1x10^6 A431 cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  FC experiment of A431 using 98523-2-RR

  1x10^6 A431 cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  FC experiment of Transfected CHO using 98523-2-RR

  1x10^6 HEK-293T cells or TNFRSF21/DR6-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  FC experiment of Transfected CHO using 98523-2-RR

  1x10^6 HEK-293T cells or TNFRSF21/DR6-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: A431-Zellen, Transfected CHO cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98523-2-RR bindet in FC TNFRSF21/DR6 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: TNFRSF21/DR6 fusion protein Eg2718
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 21
• Berechnetes Molekulargewicht: 72 kDa
• GenBank-Zugangsnummer: NM_014452.5
• Gene symbol: DR6
• Gene ID (NCBI): 27242
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

TNFRSF21 (also known as DR6 or CD358) is an orphan receptor of the tumor necrosis factor (TNF) receptor superfamily. It controls cell death and differentiation in a cell-autonomous manner in different cell types including neurons, oligodendrocytes, endothelial cells, and immune cells (PMID: 29459438). DR6 has been shown to activate NF-κB and JNK, and induce cell apoptosis (PMID: 9714541). DR6 interacts with TRADD, which is known to mediate signal transduction of TNF receptors. It has been reported that APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, indicating that DR6 might be involved in Alzheimer's disease (PMID: 19225519).